Lauramine Oxide Synthesis Essay

IUPAC name

N,N-Dimethyldodecan-1-amine oxide

Other names

Lauramine oxide; Dodecyldimethylamine oxide; Dimethyldodecylamine-N-oxide


CAS Number

3D model (JSmol)

ECHA InfoCard100.015.183
EC Number216-700-6



  • InChI=1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3 N
  • InChI=1/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3





Chemical formula

Molar mass229.41 g·mol−1
AppearanceWhite solid
Density0.996 g/ml
Boiling point132–133 °C (270–271 °F; 405–406 K)
Surface tension:


1.70 mM[1][2]
Safety data sheet[3]
GHS pictograms[3]
GHS signal wordDanger[3]

GHS hazard statements


GHS precautionary statements

P280, P305+351+338, P310[3]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)
Infobox references

Lauryldimethylamine oxide (LDAO), also known as dodecyldimethylamine oxide (DDAO), is an amine oxide based nonionic surfactant, with a C12 (dodecyl) alkyl tail. It is one of the most frequently-used surfactants of this type.[4] Like other amine oxide based surfactants it is antimicrobial, being effective against common bacteria such as S. aureus and E. coli,[1] however it is also non-denaturing and may be used to solubilize proteins.

At high concentrations, DDAO forms liquid crystalline phases.[5] Despite having only one polar atom that is able to interact with water – the oxygen atom (the quaternary nitrogen atom is hidden from intermolecular interactions), DDAO is a strongly hydrophilic surfactant: it forms normal micelles and normal liquid crystalline phases. High hydrophilicity of this surfactant can be explained by the fact that it forms very strong hydrogen bonds with water: the energy of DDAO – water hydrogen bond is about 50 kJ/mol.[6]

See also[edit]


  1. ^ abBirnie, C. R.; Malamud, D.; Schnaare, R. L. (1 September 2000). "Antimicrobial Evaluation of N-Alkyl Betaines and N-Alkyl-N,N-Dimethylamine Oxides with Variations in Chain Length". Antimicrobial Agents and Chemotherapy. 44 (9): 2514–2517. doi:10.1128/AAC.44.9.2514-2517.2000. 
  2. ^Hoffmann, H. (1990). "Correlation between surface and interfacial tensions with micellar structures and properties of surfactant solutions". 83: 16–28. doi:10.1007/BFb0116238. 
  3. ^ abcdeSigma-Aldrich Co., N,N-Dimethyldodecylamine N-oxide. Retrieved on 2017-01-04.
  4. ^Friedli, Floyd E (2001). Detergency of Specialty Surfactants. New York, NY: Dekker. ISBN 0-8247-0491-6. 
  5. ^Kocherbitov, V., Söderman, O. (2006). "Hydration of Dimethyldodecylamine-N-Oxide: Enthalpy and Entropy Driven Processes". J. Phys. Chem. B. 110 (27): 13649–13655. doi:10.1021/jp060934v. PMID 16821893. 
  6. ^Kocherbitov, V.; Veryazov, V.; Söderman, O. (2007). "Hydration of Trimethylamine-N-oxide and of Dimethyldodecylamine-N-oxide: An Ab Initio study". J. Molec. Struct. Theochem. 808: 111–118. doi:10.1016/j.theochem.2006.12.043. 

ГЛАВА 32 Дэвид Беккер остановился в коридоре у номера 301. Он знал, что где-то за этой витиеватой резной дверью находится кольцо. Вопрос национальной безопасности. За дверью послышалось движение, раздались голоса. Он постучал.

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